Sequence Detail

ID/Version

P46414 Q8BG74 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Cyclin-dependent kinase inhibitor 1B;AltName: Full=Cyclin-dependent kinase inhibitor p27 {ECO:0000303|PubMed:8033213};AltName: Full=p27Kip1 {ECO:0000303|PubMed:8033212};

Provider

SWISS-PROT

Sequence

Polypeptide 197 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdkn1b	cyclin dependent kinase inhibitor 1B	108	182	4	27

Sequence references in MGI

J:19217 Polyak K, et al., Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994 Jul 15;78(1):59-66
J:19218 Toyoshima H, et al., p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 1994 Jul 15;78(1):67-74
J:28743 Poon RY, et al., Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol Biol Cell. 1995 Sep;6(9):1197-213
J:53468 Tomoda K, et al., Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 [see comments]. Nature. 1999 Mar 11;398(6723):160-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106136 Kotake Y, et al., Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J Biol Chem. 2005 Jan 14;280(2):1095-102
J:162977 Barbash O, et al., Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation. Oncogene. 2009 Dec 10;28(49):4317-25
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89