Sequence Detail

ID/Version

P46096 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Synaptotagmin-1 {ECO:0000250|UniProtKB:P21707};AltName: Full=Synaptotagmin I {ECO:0000303|PubMed:11242035}; Short=SytI;AltName: Full=p65 {ECO:0000250|UniProtKB:P21707};

Provider

SWISS-PROT

Sequence

Polypeptide 421 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Syt1	synaptotagmin I	155	114	4	16

Sequence references in MGI

J:21503 Fukuda M, et al., Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II. J Biol Chem. 1994 Nov 18;269(46):29206-11
J:76452 Fernandez-Chacon R, et al., Synaptotagmin I functions as a calcium regulator of release probability. Nature. 2001 Mar 1;410(6824):41-9
J:95183 Lazzell DR, et al., SV2B regulates synaptotagmin 1 by direct interaction. J Biol Chem. 2004 Dec 10;279(50):52124-31
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:193895 Cao P, et al., Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. J Neurosci. 2013 Jan 23;33(4):1714-27
J:229369 Cao P, et al., Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell. 2011 Apr 15;145(2):300-11
J:235086 Valente P, et al., PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery. Cell Rep. 2016 Apr 5;15(1):117-31
J:276382 Maximov A, et al., Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. J Cell Biol. 2007 Jan 1;176(1):113-24
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89