Sequence Detail

ID/Version

P45591 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Cofilin-2;AltName: Full=Cofilin, muscle isoform;

Provider

SWISS-PROT

Sequence

Polypeptide 166 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cfl2	cofilin 2, muscle	32	104	3	26

Sequence references in MGI

J:18330 Ono S, et al., Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle. J Biol Chem. 1994 May 27;269(21):15280-6
J:182571 Agrawal PB, et al., Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet. 2012 May 15;21(10):2341-56
J:233564 Gurniak CB, et al., Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance. Eur J Cell Biol. 2014 May-Jun;93(5-6):252-66
J:233587 Vartiainen MK, et al., The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. Mol Biol Cell. 2002 Jan;13(1):183-94
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89