Sequence Detail

ID/Version

P45481 E9QPH4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Histone lysine acetyltransferase CREBBP; EC=2.3.1.48 {ECO:0000269|PubMed:11115394};AltName: Full=Protein-lysine acetyltransferase CREBBP; EC=2.3.1.- {ECO:0000269|PubMed:15220471};

Provider

SWISS-PROT

Sequence

Polypeptide 2441 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Crebbp	CREB binding protein	164	129	4	30

Sequence references in MGI

J:32922 Kamei Y, et al., A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996 May 3;85(3):403-14
J:34578 Chrivia JC, et al., Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9
J:42181 Torchia J, et al., The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature. 1997 Jun 12;387(6634):677-84
J:61379 Yahata T, et al., The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000 Mar 24;275(12):8825-34
J:80801 Yahata T, et al., Cloning of Mouse cited4, a Member of the CITED Family p300/CBP-Binding Transcriptional Coactivators: Induced Expression in Mammary Epithelial Cells. Genomics. 2002 Dec;80(6):601-13
J:132209 Mehra-Chaudhary R, et al., Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. Biochem J. 2001 Jan 1;353(Pt 1):13-22
J:132651 Cho G, et al., Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling. Mol Cell Biol. 2008 Mar;28(5):1565-72
J:172494 Shetty S, et al., Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300). Biochem J. 1999 May 1;339(Pt 3):751-8
J:178279 Daitoku H, et al., Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10042-7
J:183225 Rossow KL, et al., Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. Oncogene. 2003 Jan 9;22(1):151-6
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:209570 Anafi RC, et al., Machine learning helps identify CHRONO as a circadian clock component. PLoS Biol. 2014 Apr;12(4):e1001840
J:240295 De Guzman RN, et al., Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J Biol Chem. 2004 Jan 23;279(4):3042-9
J:256787 Li X, et al., Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017 Jun 1;66(5):684-697.e9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89