Sequence Detail

ID/Version

P43432 Q9QUM1 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interleukin-12 subunit beta; Short=IL-12B;AltName: Full=Cytotoxic lymphocyte maturation factor 40 kDa subunit; Short=CLMF p40;AltName: Full=IL-12 subunit p40;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 335 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il12b	interleukin 12b	140	97	4	17

Sequence references in MGI

J:1053 Schoenhaut DS, et al., Cloning and expression of murine IL-12. J Immunol. 1992 Jun 1;148(11):3433-40
J:33421 Tone Y, et al., Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. Eur J Immunol. 1996 Jun;26(6):1222-7
J:56752 Teuscher C, et al., Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. J Immunol. 1999 Aug 15;163(4):2262-6
J:65966 Oppmann B, et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000 Nov;13(5):715-25
J:329183 Merkley SD, et al., Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation. J Crohns Colitis. 2022 Feb 23;16(2):259-274