Sequence Detail

ID/Version

P43431 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interleukin-12 subunit alpha; Short=IL-12A;AltName: Full=Cytotoxic lymphocyte maturation factor 35 kDa subunit; Short=CLMF p35;AltName: Full=IL-12 subunit p35;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 215 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il12a	interleukin 12a	71	97	4	22

Sequence references in MGI

J:1053 Schoenhaut DS, et al., Cloning and expression of murine IL-12. J Immunol. 1992 Jun 1;148(11):3433-40
J:30856 Yoshimoto T, et al., Molecular cloning and characterization of murine IL-12 genes. J Immunol. 1996 Feb 1;156(3):1082-8
J:33421 Tone Y, et al., Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. Eur J Immunol. 1996 Jun;26(6):1222-7
J:34164 Mattner F, et al., Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol. 1996 Jul;26(7):1553-9
J:127800 Collison LW, et al., The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007 Nov 22;450(7169):566-9
J:329183 Merkley SD, et al., Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation. J Crohns Colitis. 2022 Feb 23;16(2):259-274