Sequence Detail

ID/Version

P42586 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Homeobox protein Nkx-2.2;AltName: Full=Homeobox protein NK-2 homolog B;

Provider

SWISS-PROT

Sequence

Polypeptide 273 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nkx2-2	NK2 homeobox 2	60	243	4	16

Sequence references in MGI

J:2959 Price M, et al., Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 1992 Feb;8(2):241-55
J:31775 Hartigan DJ, et al., The cDNA sequence of murine Nkx-2.2. Gene. 1996 Feb 12;168(2):271-2
J:65594 Sander M, et al., Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development. 2000 Dec;127(24):5533-40
J:70444 Rubenstein JL, et al., The embryonic vertebrate forebrain: the prosomeric model. Science. 1994 Oct 28;266(5185):578-80
J:86307 Sun T, et al., Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci. 2003 Oct 22;23(29):9547-56
J:156329 Anderson KR, et al., Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 6;284(45):31236-48