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Sequence Detail
ID/Version
P42582 P97335 (UniProt | EBI) Last sequence update: 1995-11-01
Last annotation update: 2019-06-05
Sequence
description
from provider
RecName: Full=Homeobox protein Nkx-2.5;AltName: Full=Cardiac-specific homeobox;AltName: Full=Homeobox protein CSX;AltName: Full=Homeobox protein NK-2 homolog E;
Provider SWISS-PROT
Sequence
Polypeptide 318 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Nkx2-5 NK2 homeobox 5 138 82 9 30
Sequence references in MGI J:14414 Komuro I, et al., Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8145-9
J:15282 Lints TJ, et al., Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants [published erratum appears in Development 1993 Nov;119(3):969]. Development. 1993 Oct;119(2):419-31
J:50308 Searcy RD, et al., A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. Development. 1998 Nov;125(22):4461-70
J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
J:95125 Kim TG, et al., Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol. 2004 Dec;24(23):10151-60
J:124772 Farin HF, et al., Transcriptional Repression by the T-box Proteins Tbx18 and Tbx15 Depends on Groucho Corepressors. J Biol Chem. 2007 Aug 31;282(35):25748-59
J:166035 Lee Y, et al., The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol Cell Biol. 1998 Jun;18(6):3120-9
J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/16/2019
MGI 6.14
The Jackson Laboratory