Sequence Detail

ID/Version

P42581 B9EIJ0 O88699 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Homeobox protein HMX3;AltName: Full=Homeobox protein H6 family member 3;AltName: Full=Homeobox protein Nkx-5.1;

Provider

SWISS-PROT

Sequence

Polypeptide 356 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hmx3	H6 homeobox 3	23	128	4	8

Sequence references in MGI

J:17126 Bober E, et al., A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. Dev Biol. 1994 Mar;162(1):288-303
J:28715 Rinkwitz-Brandt S, et al., Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development. Mech Dev. 1995 Aug;52(2-3):371-81
J:37995 Rinkwitz-Brandt S, et al., Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development. Hear Res. 1996 Sep 15;99(1-2):129-38
J:45576 Hadrys T, et al., Nkx5-1 controls semicircular canal formation in the mouse inner ear. Development. 1998 Jan;125(1):33-9
J:46379 Wang W, et al., Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development. 1998 Feb;125(4):621-34
J:65447 Mennerich D, et al., Two highly related homeodomain proteins, Nkx5-1 and Nkx5-2, display different DNA binding specificities. Biol Chem. 1999 Sep;380(9):1041-8
J:73069 Wang W, et al., Hmx2 homeobox gene control of murine vestibular morphogenesis. Development. 2001 Dec;128(24):5017-29
J:84974 Zheng W, et al., The role of Six1 in mammalian auditory system development. Development. 2003 Sep;130(17):3989-4000
J:92940 Wang W, et al., Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. Dev Cell. 2004 Sep;7(3):439-53
J:104488 Ozaki H, et al., Six1 controls patterning of the mouse otic vesicle. Development. 2004 Feb;131(3):551-62
J:131207 Amendt BA, et al., Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site. J Biol Chem. 1999 Apr 23;274(17):11635-42