Sequence Detail

ID/Version

P42567 Q8C431 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Epidermal growth factor receptor substrate 15; Short=Protein Eps15;AltName: Full=Protein AF-1p;

Provider

SWISS-PROT

Sequence

Polypeptide 897 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eps15	epidermal growth factor receptor pathway substrate 15	77	103	3	16

Sequence references in MGI

J:29845 Fazioli F, et al., eps15, a novel tyrosine kinase substrate, exhibits transforming activity. Mol Cell Biol. 1993 Sep;13(9):5814-28
J:56337 Nakashima S, et al., Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J. 1999 Jul 1;18(13):3629-42
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:168194 Uezu A, et al., SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15. J Biol Chem. 2007 Sep 7;282(36):26481-9
J:184112 Uezu A, et al., Characterization of the EFC/F-BAR domain protein, FCHO2. Genes Cells. 2011 Aug;16(8):868-78
J:184122 Henne WM, et al., FCHo proteins are nucleators of clathrin-mediated endocytosis. Science. 2010 Jun 4;328(5983):1281-4
J:190256 Teckchandani A, et al., The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16
J:220514 Regan-Klapisz E, et al., Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. J Cell Sci. 2005 Oct 1;118(Pt 19):4437-50
J:230366 Brett TJ, et al., Accessory protein recruitment motifs in clathrin-mediated endocytosis. Structure. 2002 Jun;10(6):797-809
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89