Sequence Detail

ID/Version

P42228 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Signal transducer and activator of transcription 4;

Provider

SWISS-PROT

Sequence

Polypeptide 749 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Stat4	signal transducer and activator of transcription 4	35	104	2	21

Sequence references in MGI

J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
J:18883 Yamamoto K, et al., Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol Cell Biol. 1994 Jul;14(7):4342-9
J:34059 Kaplan MH, et al., Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 1996 Jul 11;382(6587):174-7
J:45985 Vinkemeier U, et al., Structure of the amino-terminal protein interaction domain of STAT-4. Science. 1998 Feb 13;279(5353):1048-52
J:88973 Park WR, et al., A mechanism underlying STAT4-mediated up-regulation of IFN-gamma induction inTCR-triggered T cells. Int Immunol. 2004 Feb;16(2):295-302
J:131811 Muromoto R, et al., BART is essential for nuclear retention of STAT3. Int Immunol. 2008 Mar;20(3):395-403
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:313015 Mehrpouya-Bahrami P, et al., STAT4 is expressed in neutrophils and promotes antimicrobial immunity. JCI Insight. 2021 Jul 22;6(14)