Sequence Detail

ID/Version

P42225 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Signal transducer and activator of transcription 1;

Provider

SWISS-PROT

Sequence

Polypeptide 749 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Stat1	signal transducer and activator of transcription 1	126	133	5	39

Sequence references in MGI

J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
J:43680 Cirri P, et al., c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells. Biochem Biophys Res Commun. 1997 Oct 20;239(2):493-7
J:100999 Giannakopoulos NV, et al., Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem Biophys Res Commun. 2005 Oct 21;336(2):496-506
J:119791 Tenoever BR, et al., Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science. 2007 Mar 2;315(5816):1274-8
J:178837 Perwitasari O, et al., Inhibitor of kappaB Kinase {epsilon} (IKK{epsilon}), STAT1, and IFIT2 Proteins Define Novel Innate Immune Effector Pathway against West Nile Virus Infection. J Biol Chem. 2011 Dec 30;286(52):44412-23
J:197518 ten Hoeve J, et al., Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol. 2002 Aug;22(16):5662-8
J:229138 Wang GX, et al., Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. Diabetes. 2014 Apr;63(4):1340-52
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:326903 Nair JS, et al., Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5971-6
J:338142 He K, et al., Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell. 2023 Jul 6;186(14):3033-3048.e20