Sequence Detail

ID/Version

P42128 O35939 Q3UHI6 Q3UN67 (UniProt | EBI)

Last sequence update: 2006-11-28
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Forkhead box protein K1 {ECO:0000303|PubMed:12446708};AltName: Full=Myocyte nuclear factor {ECO:0000303|PubMed:10792059, ECO:0000303|PubMed:8007964}; Short=MNF {ECO:0000303|PubMed:10792059, ECO:0000303|PubMed:8007964};

Provider

SWISS-PROT

Sequence

Polypeptide 719 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Foxk1	forkhead box K1	55	122	3	28

Sequence references in MGI

J:18888 Bassel-Duby R, et al., Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994 Jul;14(7):4596-605
J:42857 Yang Q, et al., Transient expression of a winged-helix protein, MNF-beta, during myogenesis. Mol Cell Biol. 1997 Sep;17(9):5236-43
J:62225 Garry DJ, et al., Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5416-21
J:81688 Hawke TJ, et al., Absence of p21CIP Rescues Myogenic Progenitor Cell Proliferative and Regenerative Capacity in Foxk1 Null Mice. J Biol Chem. 2003 Feb 7;278(6):4015-20
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105897 Wijchers PJ, et al., Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain. Brain Res. 2006 Jan 12;1068(1):23-33
J:113872 Yang Q, et al., The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B. Biochem J. 2000 Jan 15;345 Pt 2:335-43
J:122510 Meeson AP, et al., Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells. EMBO J. 2007 Apr 4;26(7):1902-12
J:168863 Shi X, et al., Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors. Stem Cells. 2010 Mar 31;28(3):462-9
J:196237 Shi X, et al., Sin3 interacts with Foxk1 and regulates myogenic progenitors. Mol Cell Biochem. 2012 Jul;366(1-2):251-8
J:199180 Sel S, et al., The transcription factor Foxk1 is expressed in developing and adult mouse neuroretina. Gene Expr Patterns. 2013 Oct;13(7):280-6
J:217746 Bowman CJ, et al., Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. Nat Cell Biol. 2014 Dec;16(12):1202-14
J:273343 Sukonina V, et al., FOXK1 and FOXK2 regulate aerobic glycolysis. Nature. 2019 Feb;566(7743):279-283
J:283202 He L, et al., mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation. Mol Cell. 2018 Jun 7;70(5):949-960.e4
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87