Sequence Detail

ID/Version

P41778 (UniProt | EBI)

Last sequence update: 2002-02-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Pre-B-cell leukemia transcription factor 1;AltName: Full=Homeobox protein PBX1;

Provider

SWISS-PROT

Sequence

Polypeptide 430 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pbx1	pre B cell leukemia homeobox 1	92	141	4	22

Sequence references in MGI

J:19302 Kagawa N, et al., A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for the homeodomain protein Pbx1. J Biol Chem. 1994 Jul 22;269(29):18716-9
J:42999 Chang CP, et al., Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol Cell Biol. 1997 Oct;17(10):5679-87
J:116355 Liu Y, et al., DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. J Biol Chem. 2001 May 25;276(21):17985-93
J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
J:211245 Mojsin M, et al., PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. Biochem J. 2010 Jan 1;425(1):107-16
J:238542 Shen WF, et al., HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. Mol Cell Biol. 1999 Apr;19(4):3051-61
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:295468 Xu X, et al., PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter. FASEB J. 2020 May;34(5):6479-6492