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Sequence Detail
ID/Version
P41731 (UniProt | EBI) Last sequence update: 2007-01-23
Last annotation update: 2019-10-16
Sequence
description
from provider
RecName: Full=CD63 antigen;AltName: CD_antigen=CD63;
Provider SWISS-PROT
Sequence
Polypeptide 238 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Cd63 CD63 antigen 44 4 8 30
Sequence references in MGI J:17595 Miyamoto H, et al., Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages. Biochim Biophys Acta. 1994 Apr 6;1217(3):312-6
J:145741 Schroder J, et al., Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. Mol Cell Biol. 2009 Feb;29(4):1083-94
J:166710 Flannery AR, et al., Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes. J Cell Biol. 2010 Nov 1;191(3):599-613
J:178416 Doyle EL, et al., CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. Blood. 2011 Oct 13;118(15):4265-73
J:199599 Tugues S, et al., Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo. J Biol Chem. 2013 Jun 28;288(26):19060-71
J:205899 Kraft S, et al., The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. J Immunol. 2013 Sep 15;191(6):2871-8
J:210084 van Niel G, et al., The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev Cell. 2011 Oct 18;21(4):708-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory