Sequence Detail

ID/Version

P41251 Q3TB84 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Natural resistance-associated macrophage protein 1; Short=NRAMP 1 {ECO:0000303|PubMed:11237855};AltName: Full=Solute carrier family 11 member 1;

Provider

SWISS-PROT

Sequence

Polypeptide 548 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	115	98	3	15

Sequence references in MGI

J:4762 Vidal SM, et al., Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell. 1993 May 7;73(3):469-85
J:17877 Barton CH, et al., NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain. J Exp Med. 1994 May 1;179(5):1683-7
J:25627 Govoni G, et al., Genomic structure, promoter sequence, and induction of expression of the mouse Nramp1 gene in macrophages. Genomics. 1995 May 1;27(1):9-19
J:35004 Govoni G, et al., The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele. Infect Immun. 1996 Aug;64(8):2923-9
J:36664 Vidal SM, et al., Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains. J Immunol. 1996 Oct 15;157(8):3559-68
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:335659 Searle S, et al., Localisation of Nramp1 in macrophages: modulation with activation and infection. J Cell Sci. 1998 Oct;111 ( Pt 19):2855-66