Sequence Detail

ID/Version

P41234 (UniProt | EBI)

Last sequence update: 2005-04-12
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=ATP-binding cassette sub-family A member 2 {ECO:0000305}; EC=7.6.2.- {ECO:0000250|UniProtKB:Q9BZC7};AltName: Full=ATP-binding cassette transporter 2; Short=ATP-binding cassette 2;

Provider

SWISS-PROT

Sequence

Polypeptide 2434 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abca2	ATP-binding cassette, sub-family A member 2	74	102	3	7

Sequence references in MGI

J:23029 Luciani MF, et al., Cloning of two novel ABC transporters mapping on human chromosome 9. Genomics. 1994 May 1;21(1):150-9
J:117673 Mack JT, et al., 'Skittish' Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mol Cell Biol. 2007 Jan;27(1):44-53
J:123521 Sakai H, et al., ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain. J Biol Chem. 2007 Jul 6;282(27):19692-9
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:277862 Michaki V, et al., Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. J Biol Chem. 2012 Jan 6;287(2):1100-11
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297317 Calpe-Berdiel L, et al., Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice. Atherosclerosis. 2012 Aug;223(2):332-41
J:297523 Zhou C, et al., Atp-binding cassette transporter ABC2/ABCA2 in the rat brain: a novel mammalian lysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin sheaths. J Neurosci. 2001 Feb 1;21(3):849-57