Sequence Detail

ID/Version

P41160 (UniProt | EBI)

Last sequence update: 1995-02-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Leptin;AltName: Full=Obesity factor;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 167 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lep	leptin	166	109	4	20

Sequence references in MGI

J:20512 Zhang Y, et al., Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 1995 Mar 30;374(6521):479] [see comments]. Nature. 1994 Dec 1;372(6505):425-32
J:31761 Chehab FF, et al., Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet. 1996 Mar;12(3):318-20
J:49623 Lord GM, et al., Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998 Aug 27;394(6696):897-901
J:60001 Ducy P, et al., Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 2000 Jan 21;100(2):197-207
J:82334 Bates SH, et al., STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature. 2003 Feb 20;421(6925):856-9
J:132490 Cowley MA, et al., Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001 May 24;411(6836):480-4
J:163162 Ramadori G, et al., SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 2010 Jul 4;12(1):78-87
J:219525 Flak JN, et al., Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance. Nat Neurosci. 2014 Dec;17(12):1744-50
J:227387 Gonzalez RR, et al., Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem. 2006 Sep 8;281(36):26320-8
J:228103 Cassano S, et al., Leptin modulates autophagy in human CD4+CD25- conventional T cells. Metabolism. 2014 Oct;63(10):1272-9
J:228116 Otero M, et al., Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res Ther. 2005;7(3):R581-91