Sequence Detail

ID/Version

P40630 P97894 P97906 Q543I8 Q9DBM9 (UniProt | EBI)

Last sequence update: 2002-08-30
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription factor A, mitochondrial {ECO:0000305}; Short=mtTFA;AltName: Full=Testis-specific high mobility group protein; Short=TS-HMG;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 243 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tfam	transcription factor A, mitochondrial	52	125	3	16

Sequence references in MGI

J:12755 Boissonneault G, et al., A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids. Mol Cell Biol. 1993 Jul;13(7):4323-30
J:33733 Larsson NG, et al., A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat Genet. 1996 Jul;13(3):296-302
J:46387 Larsson NG, et al., Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice [see comments]. Nat Genet. 1998 Mar;18(3):231-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:128294 Kaufman BA, et al., The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures. Mol Biol Cell. 2007 Sep;18(9):3225-36
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89