Sequence Detail

ID/Version

P39655 Q8BHG4 (UniProt | EBI)

Last sequence update: 2007-09-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Polyunsaturated fatty acid lipoxygenase ALOX12 {ECO:0000250|UniProtKB:P18054}; EC=1.13.11.- {ECO:0000250|UniProtKB:P18054};AltName: Full=Arachidonate (12S)-lipoxygenase {ECO:0000305|PubMed:11256953}; Short=12S-LOX; Sh

Provider

SWISS-PROT

Sequence

Polypeptide 663 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alox12	arachidonate 12-lipoxygenase	112	101	3	11

Sequence references in MGI

J:18190 Chen XS, et al., cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem. 1994 May 13;269(19):13979-87
J:24098 Nakamura M, et al., Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells. J Histochem Cytochem. 1995 Mar;43(3):237-44
J:30181 Krieg P, et al., 12-Lipoxygenase isoenzymes in mouse skin tumor development. Mol Carcinog. 1995 Oct;14(2):118-29
J:46896 Johnson EN, et al., Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3100-5
J:55741 Johnson EN, et al., Basal transepidermal water loss is increased in platelet-type 12-lipoxygenase deficient mice. J Invest Dermatol. 1999 Jun;112(6):861-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:276497 Siebert M, et al., Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes. Biochem J. 2001 Apr 1;355(Pt 1):97-104
J:277856 Teder T, et al., Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction. J Lipid Res. 2014 Dec;55(12):2587-96
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89