Sequence Detail

ID/Version

P39654 Q4FJY9 Q5F2E3 Q6PHB2 (UniProt | EBI)

Last sequence update: 2007-09-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Polyunsaturated fatty acid lipoxygenase ALOX15 {ECO:0000305};AltName: Full=12/15-lipoxygenase {ECO:0000303|PubMed:8798642}; Short=12/15-LO;AltName: Full=Arachidonate 12-lipoxygenase, leukocyte-type {ECO:0000250|UniProtKB:Q02759};

Provider

SWISS-PROT

Sequence

Polypeptide 663 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alox15	arachidonate 15-lipoxygenase	111	103	3	19

Sequence references in MGI

J:18190 Chen XS, et al., cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem. 1994 May 13;269(19):13979-87
J:22314 Freire-Moar J, et al., Cloning and characterization of a murine macrophage lipoxygenase. Biochim Biophys Acta. 1995 Jan 3;1254(1):112-6
J:44778 Sun D, et al., Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem. 1996 Sep 27;271(39):24055-62
J:87403 Klein RF, et al., Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science. 2004 Jan 9;303(5655):229-32
J:98733 Gronert K, et al., A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J Biol Chem. 2005 Apr 15;280(15):15267-78
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:184646 Cole BK, et al., 12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response. Am J Physiol Endocrinol Metab. 2012 Mar;302(6):E654-65
J:187327 Uderhardt S, et al., 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity. 2012 May 25;36(5):834-46
J:200335 Miller YI, et al., 12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells. J Biol Chem. 2001 Jun 1;276(22):19431-9
J:200339 Huang JT, et al., Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature. 1999 Jul 22;400(6742):378-82
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89