Sequence Detail

ID/Version

P39447 E9QK00 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tight junction protein 1 {ECO:0000312|MGI:MGI:98759};AltName: Full=Tight junction protein ZO-1 {ECO:0000303|PubMed:8486731};AltName: Full=Zona occludens protein 1;AltName: Full=Zonula occludens protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 1745 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tjp1	tight junction protein 1	98	211	4	24

Sequence references in MGI

J:4698 Itoh M, et al., The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol. 1993 May;121(3):491-502
J:53203 Itoh M, et al., Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem. 1999 Feb 26;274(9):5981-6
J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
J:102192 Osler ME, et al., Bves modulates epithelial integrity through an interaction at the tight junction. J Cell Sci. 2005 Oct 15;118(Pt 20):4667-78
J:170871 Seeger TS, et al., Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Circ Res. 2010 Mar 19;106(5):880-90
J:208850 Hatakeyama J, et al., Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development. 2014 Apr;141(8):1671-82
J:227841 Kazmierczak M, et al., Progressive Hearing Loss in Mice Carrying a Mutation in Usp53. J Neurosci. 2015 Nov 25;35(47):15582-98
J:232161 Li G, et al., Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug;51(2):210-22
J:260802 Zhou B, et al., Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 Mar 1;128(3):970-984
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:349400 Miyazaki K, et al., Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation. PLoS One. 2016;11(3):e0152206