Sequence Detail

ID/Version

P37238 (UniProt | EBI)

Last sequence update: 2001-04-27
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Peroxisome proliferator-activated receptor gamma; Short=PPAR-gamma;AltName: Full=Nuclear receptor subfamily 1 group C member 3;

Provider

SWISS-PROT

Sequence

Polypeptide 505 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pparg	peroxisome proliferator activated receptor gamma	237	183	3	51

Sequence references in MGI

J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
J:16085 Zhu Y, et al., Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J Biol Chem. 1993 Dec 25;268(36):26817-20
J:18815 Tontonoz P, et al., mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 1994 May 15;8(10):1224-34
J:19422 Kliewer SA, et al., Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7355-9
J:22226 Tontonoz P, et al., Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994 Dec 30;79(7):1147-56
J:22537 Tontonoz P, et al., Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Res. 1994 Dec 25;22(25):5628-34
J:33358 Vidal-Puig A, et al., Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest. 1996 Jun 1;97(11):2553-61
J:43438 Zhu Y, et al., Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem. 1997 Oct 10;272(41):25500-6
J:58222 Kubota N, et al., PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell. 1999 Oct;4(4):597-609
J:58223 Barak Y, et al., PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell. 1999 Oct;4(4):585-95
J:62059 Zhu Y, et al., Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J Biol Chem. 2000 May 5;275(18):13510-6
J:95883 Drori S, et al., Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 1;19(3):362-75
J:120142 Rosen ED, et al., PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 1999 Oct;4(4):611-7
J:125396 Li D, et al., Constitutive Coactivator of Peroxisome Proliferator-Activated Receptor (PPAR{gamma}), a Novel Coactivator of PPAR{gamma} that Promotes Adipogenesis. Mol Endocrinol. 2007 Oct;21(10):2320-33
J:138823 Seale P, et al., PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21;454(7207):961-7
J:144377 Wang N, et al., Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1. Cell Metab. 2008 Dec;8(6):482-91
J:161288 Kawai M, et al., A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10508-13
J:167907 Grimaldi B, et al., PER2 controls lipid metabolism by direct regulation of PPARgamma. Cell Metab. 2010 Nov 3;12(5):509-20
J:172245 Villanueva CJ, et al., TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 2011 Apr 6;13(4):413-27
J:178732 Hinds TD Jr, et al., Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-gamma (PPARgamma). J Biol Chem. 2011 Dec 16;286(50):42911-22
J:181224 Ji S, et al., O-GlcNAc modification of PPARgamma reduces its transcriptional activity. Biochem Biophys Res Commun. 2012 Jan 27;417(4):1158-63
J:182670 Ohno H, et al., PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012 Mar 7;15(3):395-404
J:198134 Villanueva CJ, et al., Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARgamma specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013 Mar 5;17(3):423-35
J:209483 Wang F, et al., SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell. 2009 Feb;20(3):801-8
J:213153 Harms MJ, et al., Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
J:219351 Guo C, et al., The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor gamma requires G protein pathway suppressor 2. J Biol Chem. 2015 Feb 6;290(6):3666-79
J:255965 Jordan SD, et al., CRY1/2 Selectively Repress PPARdelta and Limit Exercise Capacity. Cell Metab. 2017 Jul 5;26(1):243-255.e6
J:274785 Guyot R, et al., The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR. BMC Mol Biol. 2010 Jan 15;11:3
J:355673 Qiu J, et al., PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARgamma degradation. Lab Invest. 2022 Oct;102(10):1121-1131
J:371297 Wang L, et al., YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARgamma. EMBO J. 2025 Jun;44(12):3360-3380
J:371335 Forman BM, et al., 15-Deoxy-Delta12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARgamma. Cell. 1995 Dec 1;83(5):803-12
J:371336 Kliewer SA, et al., A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9