Sequence Detail

ID/Version

P35991 Q61365 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosine-protein kinase BTK; EC=2.7.10.2;AltName: Full=Agammaglobulinemia tyrosine kinase; Short=ATK;AltName: Full=B-cell progenitor kinase; Short=BPK;AltName: Full=Bruton tyrosine kinase;AltName: Full=Kinase EMB;

Provider

SWISS-PROT

Sequence

Polypeptide 659 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Btk	Bruton agammaglobulinemia tyrosine kinase	125	99	3	744

Sequence references in MGI

J:13209 Rawlings DJ, et al., Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science. 1993 Jul 16;261(5119):358-61
J:14186 Tsukada S, et al., Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell. 1993 Jan 29;72(2):279-90
J:20701 Yamada N, et al., Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem Biophys Res Commun. 1993 Apr 15;192(1):231-40
J:21900 Sideras P, et al., Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci. J Immunol. 1994 Dec 15;153(12):5607-17
J:26928 Li T, et al., Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain. Immunity. 1995 May;2(5):451-60
J:110720 Petro JB, et al., Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. J Exp Med. 2000 May 15;191(10):1745-54
J:118397 Webb CF, et al., The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease. J Immunol. 2000 Dec 15;165(12):6956-65
J:126402 Kawakami Y, et al., Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7423-8
J:134805 Hasan M, et al., Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice. Immunology. 2008 Feb;123(2):239-49
J:266145 Rawlings DJ, et al., Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science. 1996 Feb 9;271(5250):822-5
J:266154 Park H, et al., Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity. 1996 May;4(5):515-25
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:331919 Bittner ZA, et al., BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. J Exp Med. 2021 Nov 1;218(11):e20201656
J:334006 Choi HK, et al., Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. Cell Res. 2013 Apr;23(4):524-36