Sequence Detail

ID/Version

P35969 O55094 Q61517 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Vascular endothelial growth factor receptor 1; Short=VEGFR-1; EC=2.7.10.1;AltName: Full=Embryonic receptor kinase 2;AltName: Full=Fms-like tyrosine kinase 1; Short=FLT-1;AltName: Full=Tyrosine-protein kinase receptor

Provider

SWISS-PROT

Sequence

Polypeptide 1333 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Flt1	FMS-like tyrosine kinase 1	73	164	3	13

Sequence references in MGI

J:13199 Finnerty H, et al., Molecular cloning of murine FLT and FLT4. Oncogene. 1993 Aug;8(8):2293-8
J:17437 Choi K, et al., Isolation of a gene encoding a novel receptor tyrosine kinase from differentiated embryonic stem cells. Oncogene. 1994 Apr;9(4):1261-6
J:26845 Fong GH, et al., Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995 Jul 6;376(6535):66-70
J:46564 Kondo K, et al., Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors. Gene. 1998 Feb 27;208(2):297-305
J:49507 Hiratsuka S, et al., Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9349-54
J:68578 Hiratsuka S, et al., Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res. 2001 Feb 1;61(3):1207-13
J:90967 Kearney JB, et al., The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis. Blood. 2004 Jun 15;103(12):4527-35
J:151369 Nishi J, et al., Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt. Circ Res. 2008 Aug 1;103(3):261-8
J:165563 Muramatsu M, et al., Vascular endothelial growth factor receptor-1 signaling promotes mobilization of macrophage lineage cells from bone marrow and stimulates solid tumor growth. Cancer Res. 2010 Oct 15;70(20):8211-21
J:279052 Nguyen MT, et al., An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nat Cell Biol. 2019 Apr;21(4):420-429