Sequence Detail

ID/Version

P35922 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Fragile X messenger ribonucleoprotein 1 {ECO:0000305};AltName: Full=Fragile X messenger ribonucleoprotein {ECO:0000305}; Short=FMRP {ECO:0000303|PubMed:10567518};AltName: Full=Protein FMR-1 {ECO:0000303|PubMed:8358432}; Short

Provider

SWISS-PROT

Sequence

Polypeptide 614 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fmr1	fragile X messenger ribonucleoprotein 1	281	128	3	26

Sequence references in MGI

J:12844 Ashley CT, et al., Human and murine FMR-1: alternative splicing and translational initiation downstream of the CGG-repeat. Nat Genet. 1993 Jul;4(3):244-51
J:19220 Bakker CE, et al., Fmr1 knockout mice: a model to study fragile x mental retardation. The Dutch-Belgium Fragile X Consortium. Cell. 1994 Jul 15;78(1):23-33
J:58813 Bardoni B, et al., A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. Hum Mol Genet. 1999 Dec;8(13):2557-66
J:70178 Nimchinsky EA, et al., Abnormal development of dendritic spines in FMR1 knock-out mice. J Neurosci. 2001 Jul 15;21(14):5139-46
J:70399 Comery TA, et al., Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5401-4
J:76865 Huber KM, et al., Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50
J:87312 Wang H, et al., Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors. Hum Mol Genet. 2004 Jan 1;13(1):79-89
J:88664 Schenck A, et al., A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8844-9
J:92378 Khandjian EW, et al., Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13357-62
J:93541 Lu R, et al., The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15201-6
J:94717 Weiler IJ, et al., Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses. Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17504-9
J:96571 Kanai Y, et al., Kinesin transports RNA: isolation and characterization of an RNA-transporting granule. Neuron. 2004 Aug 19;43(4):513-25
J:97555 Darnell JC, et al., Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev. 2005 Apr 15;19(8):903-18
J:103915 Huot ME, et al., The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis. Mol Biol Cell. 2005 Sep;16(9):4350-61
J:104472 Stetler A, et al., Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp. Hum Mol Genet. 2006 Jan 1;15(1):87-96
J:107689 Miyashiro KY, et al., RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron. 2003 Feb 6;37(3):417-31
J:111946 Antar LN, et al., Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses. Mol Cell Neurosci. 2006 May-Jun;32(1-2):37-48
J:112066 Spencer CM, et al., Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins. Hum Mol Genet. 2006 Jun 15;15(12):1984-94
J:121659 Zalfa F, et al., A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat Neurosci. 2007 May;10(5):578-87
J:122268 Zhang M, et al., Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10057-62
J:122974 Hou L, et al., Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression. Neuron. 2006 Aug 17;51(4):441-54
J:137197 Dictenberg JB, et al., A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev Cell. 2008 Jun;14(6):926-39
J:143833 Muddashetty RS, et al., Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome. J Neurosci. 2007 May 16;27(20):5338-48
J:144699 Bechara EG, et al., A novel function for fragile X mental retardation protein in translational activation. PLoS Biol. 2009 Jan 20;7(1):e16
J:144942 Christie SB, et al., The FXG: a presynaptic Fragile X granule expressed in a subset of developing brain circuits. J Neurosci. 2009 Feb 4;29(5):1514-24
J:156046 Napoli I, et al., The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 2008 Sep 19;134(6):1042-54
J:156357 Schutt J, et al., Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities. J Biol Chem. 2009 Sep 18;284(38):25479-87
J:161627 Brown MR, et al., Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nat Neurosci. 2010 Jul;13(7):819-21
J:167653 Edbauer D, et al., Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron. 2010 Feb 11;65(3):373-84
J:173059 Didiot MC, et al., The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer. Nucleic Acids Res. 2008 Sep;36(15):4902-12
J:174610 Darnell JC, et al., FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism. Cell. 2011 Jul 22;146(2):247-61
J:194411 Ascano M Jr, et al., FMRP targets distinct mRNA sequence elements to regulate protein expression. Nature. 2012 Dec 20;492(7429):382-6
J:204807 Mazroui R, et al., Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression. Hum Mol Genet. 2002 Nov 15;11(24):3007-17
J:211150 Derlig K, et al., Identification and characterisation of Simiate, a novel protein linked to the fragile X syndrome. PLoS One. 2013;8(12):e83007
J:214017 Giampetruzzi A, et al., FMRP and myelin protein expression in oligodendrocytes. Mol Cell Neurosci. 2013 Sep;56:333-41
J:214397 Alpatov R, et al., A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell. 2014 May 8;157(4):869-81
J:230624 Piazzon N, et al., In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein. J Biol Chem. 2008 Feb 29;283(9):5598-610
J:230638 Menon RP, et al., The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. J Mol Biol. 2004 Oct 8;343(1):43-53
J:231207 Li Z, et al., The fragile X mental retardation protein inhibits translation via interacting with mRNA. Nucleic Acids Res. 2001 Jun 1;29(11):2276-83
J:231209 Ceman S, et al., Identification of mouse YB1/p50 as a component of the FMRP-associated mRNP particle. Biochem Biophys Res Commun. 2000 Dec 29;279(3):904-8
J:231210 Ceman S, et al., Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex. Mol Cell Biol. 1999 Dec;19(12):7925-32
J:231248 Ferron L, et al., Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density. Nat Commun. 2014;5:3628
J:231287 Lai D, et al., The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2. RNA. 2006 Aug;12(8):1446-9
J:232980 Myrick LK, et al., Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):949-56
J:232981 Kenny PJ, et al., MOV10 and FMRP regulate AGO2 association with microRNA recognition elements. Cell Rep. 2014 Dec 11;9(5):1729-41
J:257376 Zalfa F, et al., The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell. 2003 Feb 7;112(3):317-27
J:263455 Wang GX, et al., Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses. Elife. 2016 Oct 22;5:e20560
J:282866 Hsu PJ, et al., The RNA-binding protein FMRP facilitates the nuclear export of N (6)-methyladenosine-containing mRNAs. J Biol Chem. 2019 Dec 27;294(52):19889-19895
J:285490 Edens BM, et al., FMRP Modulates Neural Differentiation through m(6)A-Dependent mRNA Nuclear Export. Cell Rep. 2019 Jul 23;28(4):845-854.e5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87