Sequence Detail

ID/Version

P35918 Q8VCD0 C5H7S5 (UniProt | EBI)

Last sequence update: 2021-02-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Vascular endothelial growth factor receptor 2 {ECO:0000305}; Short=VEGFR-2; EC=2.7.10.1 {ECO:0000269|PubMed:12881528};AltName: Full=Fetal liver kinase 1; Short=FLK-1;AltName: Full=Kinase NYK;AltName: Full=Protein-tyro

Provider

SWISS-PROT

Sequence

Polypeptide 1345 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kdr	kinase insert domain protein receptor	227	325	3	35

Sequence references in MGI

J:1615 Matthews W, et al., A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9026-30
J:14638 Oelrichs RB, et al., NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo. Oncogene. 1993 Jan;8(1):11-18
J:26846 Shalaby F, et al., Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995 Jul 6;376(6535):62-6
J:29056 Patterson C, et al., Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem. 1995 Sep 29;270(39):23111-8
J:36300 Millauer B, et al., High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell. 1993 Mar 26;72(6):835-46
J:91451 Quinn TP, et al., Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7533-7
J:152727 Kanemura H, et al., Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1. Biochem Biophys Res Commun. 2009 Oct 2;387(4):754-9
J:154336 Albuquerque RJ, et al., Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med. 2009 Sep;15(9):1023-30
J:163126 Bernatchez PN, et al., Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. J Biol Chem. 2007 Oct 19;282(42):30745-53
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89