Sequence Detail

ID/Version

P35831 Q80UM4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosine-protein phosphatase non-receptor type 12; EC=3.1.3.48 {ECO:0000269|PubMed:7772023};AltName: Full=MPTP-PEST;AltName: Full=Protein-tyrosine phosphatase P19; Short=P19-PTP;

Provider

SWISS-PROT

Sequence

Polypeptide 775 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptpn12	protein tyrosine phosphatase, non-receptor type 12	44	106	3	27

Sequence references in MGI

J:24425 Charest A, et al., Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase. Biochem J. 1995 Jun 1;308(Pt 2):425-32
J:25662 den Hertog J, et al., Differential expression of a novel murine non-receptor protein tyrosine phosphatase during differentiation of P19 embryonal carcinoma cells. Biochem Biophys Res Commun. 1992 May 15;184(3):1241-9
J:54072 Nishiya N, et al., Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain. J Biol Chem. 1999 Apr 2;274(14):9847-53
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:119668 Sirois J, et al., Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech Dev. 2006 Dec;123(12):869-80
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:180487 Gupta A, et al., Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. J Bone Miner Res. 2003 Apr;18(4):669-85
J:180575 Watanabe N, et al., Leupaxin binds to PEST domain tyrosine phosphatase PEP. Mol Cell Biochem. 2005 Jan;269(1-2):13-7
J:200330 Cote JF, et al., PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP. J Biol Chem. 2002 Jan 25;277(4):2973-86
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89