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Sequence Detail
ID/Version
P35762 Q91V78 (UniProt | EBI) Last sequence update: 2012-10-03
Last annotation update: 2019-10-16
Sequence
description
from provider
RecName: Full=CD81 antigen;AltName: Full=26 kDa cell surface protein TAPA-1;AltName: Full=Target of the antiproliferative antibody 1 {ECO:0000303|PubMed:11046035};AltName: CD_antigen=CD81;
Provider SWISS-PROT
Sequence
Polypeptide 236 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Cd81 CD81 antigen 62 14 10 25
Sequence references in MGI J:11355 Andria ML, et al., Genomic organization and chromosomal localization of the TAPA-1 gene. J Immunol. 1991 Aug 1;147(3):1030-6
J:63702 Paulsen M, et al., Sequence conservation and variability of imprinting in the beckwith-wiedemann syndrome gene cluster in human and mouse. Hum Mol Genet. 2000 Jul 22;9(12):1829-41
J:65423 Deng J, et al., Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice. J Immunol. 2000 Nov 1;165(9):5054-61
J:72670 Clark KL, et al., Pgrl is a major cd81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. J Immunol. 2001 Nov 1;167(9):5115-21
J:83795 Takeda Y, et al., Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J Cell Biol. 2003 Jun 9;161(5):945-56
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105963 Rubinstein E, et al., Reduced fertility of female mice lacking CD81. Dev Biol. 2006 Feb 15;290(2):351-8
J:126000 Silvie O, et al., Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Nat Med. 2003 Jan;9(1):93-6
J:130090 Tanigawa M, et al., Possible involvement of CD81 in acrosome reaction of sperm in mice. Mol Reprod Dev. 2008 Jan;75(1):150-5
J:141975 Takeda Y, et al., Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice. J Biol Chem. 2008 Sep 19;283(38):26089-97
J:185340 Ohnami N, et al., CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte. Biol Open. 2012 Jul 15;1(7):640-7
J:195115 Mattila PK, et al., The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. Immunity. 2013 Mar 21;38(3):461-74
J:197437 Bhave VS, et al., Regulation of liver growth by glypican 3, CD81, hedgehog, and hhex. Am J Pathol. 2013 Jul;183(1):153-9
J:271693 Charrin S, et al., Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81. Nat Commun. 2013;4:1674

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory