Sequence Detail

ID/Version

P35583 A2AR89 Q60602 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Hepatocyte nuclear factor 3-beta; Short=HNF-3-beta; Short=HNF-3B;AltName: Full=Forkhead box protein A2;

Provider

SWISS-PROT

Sequence

Polypeptide 459 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Foxa2	forkhead box A2	111	370	3	24

Sequence references in MGI

J:11921 Sasaki H, et al., Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development. 1993 May;118(1):47-59
J:16244 Ang SL, et al., The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development. 1993 Dec;119(4):1301-15
J:17631 Kaestner KH, et al., The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution. Genomics. 1994 Apr;20(3):377-85
J:19895 Ang SL, et al., HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26;78(4):561-74
J:70409 Sund NJ, et al., Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev. 2001 Jul 1;15(13):1706-15
J:95662 Wolfrum C, et al., Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature. 2004 Dec 23;432(7020):1027-32
J:98750 Wan H, et al., Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem. 2005 Apr 8;280(14):13809-16
J:99346 Lee CS, et al., The initiation of liver development is dependent on Foxa transcription factors. Nature. 2005 Jun 16;435(7044):944-7
J:124122 Ferri AL, et al., Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development. 2007 Aug;134(15):2761-9
J:134070 van der Sluis M, et al., Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells. Biochem Biophys Res Commun. 2008 May 16;369(4):1108-13
J:143476 Gao N, et al., Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev. 2008 Dec 15;22(24):3435-48
J:150580 Li Z, et al., Foxa1 and Foxa2 regulate bile duct development in mice. J Clin Invest. 2009 Jun;119(6):1537-45
J:175106 Wang H, et al., Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. J Biol Chem. 2002 May 17;277(20):17564-70
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89