Sequence Detail

ID/Version

P35582 Q4VA63 Q61108 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Hepatocyte nuclear factor 3-alpha; Short=HNF-3-alpha; Short=HNF-3A;AltName: Full=Forkhead box protein A1;

Provider

SWISS-PROT

Sequence

Polypeptide 468 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Foxa1	forkhead box A1	96	167	3	11

Sequence references in MGI

J:17631 Kaestner KH, et al., The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution. Genomics. 1994 Apr;20(3):377-85
J:53312 Kaestner KH, et al., Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev. 1999 Feb 15;13(4):495-504
J:93462 Behr R, et al., Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency. J Biol Chem. 2004 Nov 1;279(40):41936-41
J:98750 Wan H, et al., Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem. 2005 Apr 8;280(14):13809-16
J:99346 Lee CS, et al., The initiation of liver development is dependent on Foxa transcription factors. Nature. 2005 Jun 16;435(7044):944-7
J:101172 Gao N, et al., Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development. 2005 Aug;132(15):3431-43
J:118897 Minoo P, et al., Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells. Mol Cell Biol. 2007 Mar;27(6):2155-65
J:124122 Ferri AL, et al., Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development. 2007 Aug;134(15):2761-9
J:143476 Gao N, et al., Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev. 2008 Dec 15;22(24):3435-48
J:150580 Li Z, et al., Foxa1 and Foxa2 regulate bile duct development in mice. J Clin Invest. 2009 Jun;119(6):1537-45
J:161021 Holmqvist PH, et al., FoxA1 binding to the MMTV LTR modulates chromatin structure and transcription. Exp Cell Res. 2005 Apr 1;304(2):593-603