Sequence Detail

ID/Version

P35546 Q9QXH9 Q8BQ34 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret; EC=2.7.10.1;AltName: Full=Proto-oncogene c-Ret;Contains: RecName: Full=Soluble RET kinase fragment;Contains: RecName: Full=Extracellular cell-membrane anchored RET cadherin 120 k

Provider

SWISS-PROT

Sequence

Polypeptide 1115 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ret	ret proto-oncogene	108	249	3	59

Sequence references in MGI

J:41301 Iwamoto T, et al., cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily. Oncogene. 1993 Apr;8(4):1087-91
J:70544 Grimm J, et al., Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol. 2001 Jul 23;154(2):345-54
J:87966 Shi N, et al., Structural basis for the specific recognition of RET by the Dok1 phosphotyrosine binding domain. J Biol Chem. 2004 Feb 6;279(6):4962-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106244 Yan H, et al., Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev Biol. 2004 Aug 1;272(1):118-33
J:120816 Veiga-Fernandes H, et al., Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature. 2007 Mar 29;446(7135):547-51
J:138788 Tsui CC, et al., CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. J Neurosci. 2008 Aug 27;28(35):8789-800
J:159107 Golden JP, et al., RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J Neurosci. 2010 Mar 17;30(11):3983-94
J:251981 Yang L, et al., GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Nat Med. 2017 Oct;23(10):1158-1166
J:254140 Hsu JY, et al., Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature. 2017 Oct 12;550(7675):255-259