Sequence Detail

ID/Version

P35436 (UniProt | EBI)

Last sequence update: 2004-07-19
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Glutamate receptor ionotropic, NMDA 2A {ECO:0000305}; Short=GluN2A;AltName: Full=Glutamate [NMDA] receptor subunit epsilon-1 {ECO:0000303|PubMed:1374164};AltName: Full=N-methyl D-aspartate receptor subtype 2A; Short=NMDAR2A;

Provider

SWISS-PROT

Sequence

Polypeptide 1464 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	212	112	4	23

Sequence references in MGI

J:17924 Meguro H, et al., Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature. 1992 May 7;357(6373):70-4
J:22295 Sakimura K, et al., Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature. 1995 Jan 12;373(6510):151-5
J:66455 Kadotani H, et al., Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci. 1996 Dec 15;16(24):7859-67
J:119798 Metzler M, et al., NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1. J Neurosci. 2007 Feb 28;27(9):2298-308
J:145953 Ng D, et al., Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol. 2009 Feb 24;7(2):e41
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:198375 Wang X, et al., Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr;19(4):473-80
J:244563 Ma Q, et al., SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease. JCI Insight. 2017 May 04;2(9)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:345001 Park H, et al., Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol Brain. 2015 Feb 3;8:7
J:354155 Matsuda K, et al., Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability. Brain Res Mol Brain Res. 2002 Apr 30;100(1-2):43-52
J:360498 Matsui T, et al., Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J Neurochem. 1995 Jul;65(1):454-8