Sequence Detail

ID/Version

P35288 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Ras-related protein Rab-23;AltName: Full=Protein open brain;AltName: Full=Rab-15;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 237 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rab23	RAB23, member RAS oncogene family	47	105	3	20

Sequence references in MGI

J:16892 Olkkonen VM, et al., Isolation of a mouse cDNA encoding Rab23, a small novel GTPase expressed predominantly in the brain. Gene. 1994 Jan 28;138(1-2):207-11
J:21617 Gunther T, et al., Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development. 1994 Nov;120(11):3119-30
J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
J:65763 Eggenschwiler JT, et al., Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. Dev Biol. 2000 Nov 15;227(2):648-60
J:70423 Eggenschwiler JT, et al., Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature. 2001 Jul 12;412(6843):194-8
J:104803 Eggenschwiler JT, et al., Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins. Dev Biol. 2006 Feb 1;290(1):1-12
J:154835 Eathiraj S, et al., Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature. 2005 Jul 21;436(7049):415-9
J:196275 Guo A, et al., Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization. J Neurosci Res. 2006 May 1;83(6):1118-27
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89