Sequence Detail

ID/Version

P35235 Q6PCL5 Q64509 Q3TQ84 (UniProt | EBI)

Last sequence update: 2019-12-11
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Tyrosine-protein phosphatase non-receptor type 11; EC=3.1.3.48 {ECO:0000250|UniProtKB:Q06124};AltName: Full=Protein-tyrosine phosphatase SYP;AltName: Full=SH-PTP2; Short=SHP-2; Short=Shp2;

Provider

SWISS-PROT

Sequence

Polypeptide 593 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptpn11	protein tyrosine phosphatase, non-receptor type 11	152	105	3	49

Sequence references in MGI

J:19469 Feng GS, et al., SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science. 1993 Mar 12;259(5101):1607-11
J:36295 Ohnishi H, et al., Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule. J Biol Chem. 1996 Oct 11;271(41):25569-74
J:39778 Liu L, et al., Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2. J Biol Chem. 1997 Apr 25;272(17):10998-1001
J:51814 Huber M, et al., The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. J Biol Chem. 1999 Jan 1;274(1):335-44
J:53418 Nishida K, et al., Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood. 1999 Mar 15;93(6):1809-16
J:88290 Zhang SQ, et al., Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell. 2004 Feb 13;13(3):341-55
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112094 Charest A, et al., ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 2006 Aug 1;66(15):7473-81
J:161854 Hitomi K, et al., An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Nat Immunol. 2010 Jul;11(7):601-7
J:193456 Chen W, et al., Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation. Cell. 2013 Jan 31;152(3):467-78
J:200516 Jones N, et al., Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem. 1999 Oct 22;274(43):30896-905
J:201266 Mazharian A, et al., Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. Sci Signal. 2012;5(248):ra78
J:231275 Muller MM, et al., Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. J Cell Biol. 2009 Nov 16;187(4):569-81
J:287059 Zuo C, et al., SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity. Bone Res. 2018;6:12
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314643 Lu-Kuo JM, et al., gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. J Biol Chem. 1999 Feb 26;274(9):5791-6