Sequence Detail

ID/Version

P34968 Q5WRU6 B1ATN5 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=5-hydroxytryptamine receptor 2C {ECO:0000305}; Short=5-HT-2C; Short=5-HT2C; Short=5-HTR2C;AltName: Full=5-hydroxytryptamine receptor 1C; Short=5-HT-1C; Short=5-HT1C;AltName: Full=Serotonin receptor 2C;

Provider

SWISS-PROT

Sequence

Polypeptide 459 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	58	105	4	16

Sequence references in MGI

J:2966 Yu L, et al., The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked. Brain Res Mol Brain Res. 1991 Sep;11(2):143-9
J:24339 Tecott LH, et al., Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors [see comments]. Nature. 1995 Apr 6;374(6522):542-6
J:40570 Foguet M, et al., Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes. Neuroreport. 1992 Apr;3(4):345-8
J:50262 Nonogaki K, et al., Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene [see comments]. Nat Med. 1998 Oct;4(10):1152-6
J:117972 Gavarini S, et al., Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability. Mol Biol Cell. 2006 Nov;17(11):4619-31
J:122977 Heisler LK, et al., Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J Neurosci. 2007 Jun 27;27(26):6956-64
J:137308 Heisler LK, et al., Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes Brain Behav. 2007 Jul;6(5):491-6
J:147514 Xu Y, et al., 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008 Nov 26;60(4):582-9
J:166702 Xu Y, et al., A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci. 2010 Nov 3;30(44):14630-4
J:166904 Xu Y, et al., 5-HT(2C)Rs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010 Dec;13(12):1457-9
J:174678 Sohn JW, et al., Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels. Neuron. 2011 Aug 11;71(3):488-97
J:179499 Fletcher PJ, et al., Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. Neuropharmacology. 2009 Sep;57(3):259-67