Sequence Detail

ID/Version

P31809 Q61353 Q61350 (UniProt | EBI)

Last sequence update: 1993-07-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 1 {ECO:0000250|UniProtKB:P13688};AltName: Full=Biliary glycoprotein 1 {ECO:0000250|UniProtKB:P13688}; Short=BGP-1;AltName: Full=Biliary glycoprotein D;AltName: Full=MHVR1;AltNam

Provider

SWISS-PROT

Sequence

Polypeptide 521 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ceacam1	CEA cell adhesion molecule 1	177	122	11	17

Sequence references in MGI

J:701 Dveksler GS, et al., Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV. J Virol. 1991 Dec;65(12):6881-91
J:12189 McCuaig K, et al., Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms. Gene. 1993 May 30;127(2):173-83
J:25438 Williams RK, et al., Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins. Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5533-6
J:51814 Huber M, et al., The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. J Biol Chem. 1999 Jan 1;274(1):335-44
J:76420 Singer BB, et al., Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. J Immunol. 2002 May 15;168(10):5139-46
J:92376 Hemmila E, et al., Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus a59. J Virol. 2004 Sep;78(18):10156-65
J:92495 Dveksler GS, et al., Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59. J Virol. 1993 Jan;67(1):1-8
J:93419 Abou-Rjaily GA, et al., CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation. J Clin Invest. 2004 Nov;114(7):944-52
J:110370 Horst AK, et al., Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo. J Clin Invest. 2006 Jun;116(6):1596-605
J:116136 Nagaishi T, et al., SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity. 2006 Nov;25(5):769-81
J:141785 DeAngelis AM, et al., Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes. 2008 Sep;57(9):2296-303
J:145563 Wong C, et al., CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 2009 Feb 19;113(8):1818-28
J:165472 Pan H, et al., Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor. Immunity. 2010 Oct 29;33(4):620-31
J:182907 Nouvion AL, et al., CEACAM1: a key regulator of vascular permeability. J Cell Sci. 2010 Dec 15;123(Pt 24):4221-30
J:190980 Chen L, et al., The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 2012 Nov 16;37(5):930-46
J:195394 Lu R, et al., CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog. 2012;8(4):e1002597
J:201200 Hosomi S, et al., CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol. 2013 Sep;43(9):2473-83
J:207881 Bickert T, et al., Acceleration of collateral development by carcinoembryonic antigen-related cell adhesion molecule 1 expression on CD11b/(+)Gr-1(+) myeloid cells--brief report. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2566-8
J:216276 McCuaig K, et al., mmCGM1a: a mouse carcinoembryonic antigen gene family member, generated by alternative splicing, functions as an adhesion molecule. Cell Growth Differ. 1992 Mar;3(3):165-74
J:217479 Huang YH, et al., CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015 Jan 15;517(7534):386-90
J:225125 Heckt T, et al., Increased osteoclastogenesis in mice lacking the carcinoembryonic antigen-related cell adhesion molecule 1. PLoS One. 2014;9(12):e114360
J:238765 Kitamura Y, et al., Regulation by gut commensal bacteria of carcinoembryonic antigen-related cell adhesion molecule expression in the intestinal epithelium. Genes Cells. 2015 Jul;20(7):578-89
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89