Sequence Detail

ID/Version

P31725 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein S100-A9;AltName: Full=Calgranulin-B;AltName: Full=Leukocyte L1 complex heavy chain;AltName: Full=Migration inhibitory factor-related protein 14; Short=MRP-14; Short=p14;AltName: Full=S100 calcium-binding protein A9;

Provider

SWISS-PROT

Sequence

Polypeptide 113 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	S100a9	S100 calcium binding protein A9 (calgranulin B)	68	104	2	19

Sequence references in MGI

J:1255 Lagasse E, et al., Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood. 1992 Apr 15;79(8):1907-15
J:33155 Raftery MJ, et al., Isolation of the murine S100 protein MRP14 (14 kDa migration-inhibitory-factor-related protein) from activated spleen cells: characterization of post-translational modifications and zinc binding. Biochem J. 1996 May 15;316(Pt 1):285-93
J:81642 Manitz MP, et al., Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro. Mol Cell Biol. 2003 Feb;23(3):1034-43
J:125179 Vogl T, et al., Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med. 2007 Sep;13(9):1042-9
J:149024 Boyd JH, et al., S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res. 2008 May 23;102(10):1239-46
J:150483 Bjork P, et al., Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides. PLoS Biol. 2009 Apr 28;7(4):e97
J:183748 Averill MM, et al., S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation. Circulation. 2011 Mar 22;123(11):1216-26
J:189636 Riva M, et al., Induction of nuclear factor-kappaB responses by the S100A9 protein is Toll-like receptor-4-dependent. Immunology. 2012 Oct;137(2):172-82
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302655 Davydova E, et al., The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nat Commun. 2021 Feb 9;12(1):891