Sequence Detail

ID/Version

P30681 Q3UXT1 Q9EQD5 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=High mobility group protein B2;AltName: Full=High mobility group protein 2; Short=HMG-2;

Provider

SWISS-PROT

Sequence

Polypeptide 210 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hmgb2	high mobility group box 2	121	126	7	11

Sequence references in MGI

J:2642 Stolzenburg F, et al., Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-2 (HMG-2) [published erratum appears in Nucleic Acids Res 1992 Oct 11;20(19):5262]. Nucleic Acids Res. 1992 Sep 25;20(18):4927
J:24361 Zwilling S, et al., High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. EMBO J. 1995 Mar 15;14(6):1198-208
J:67968 Ronfani L, et al., Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2. Development. 2001 Apr;128(8):1265-73
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:153213 Taniguchi N, et al., Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16817-22
J:154027 Yanai H, et al., HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature. 2009 Nov 5;462(7269):99-103
J:196872 Campbell PA, et al., Oct4 interaction with hmgb2 regulates akt signaling and pluripotency. Stem Cells. 2013 Jun;31(6):1107-20
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:209829 Abraham AB, et al., Aberrant neural stem cell proliferation and increased adult neurogenesis in mice lacking chromatin protein HMGB2. PLoS One. 2013;8(12):e84838
J:221515 Lee S, et al., A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat Chem Biol. 2014 Dec;10(12):1055-60
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89