Sequence Detail

ID/Version

P30561 Q99P79 Q8R4S3 Q9QVY1 Q8QZX6 (UniProt | EBI)

Last sequence update: 2003-03-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Aryl hydrocarbon receptor; Short=Ah receptor; Short=AhR;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 848 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ahr	aryl-hydrocarbon receptor	146	121	4	40

Sequence references in MGI

J:477 Ema M, et al., cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun. 1992 Apr 15;184(1):246-53
J:2256 Burbach KM, et al., Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8185-9
J:15153 Schmidt JV, et al., Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem. 1993 Oct 15;268(29):22203-9
J:17460 Chang C, et al., Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics. 1993 Dec;3(6):312-21
J:22133 Ema M, et al., Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J Biol Chem. 1994 Nov 4;269(44):27337-43
J:22144 Poland A, et al., Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol. 1994 Nov;46(5):915-21
J:35698 FitzGerald CT, et al., Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins. Arch Biochem Biophys. 1996 Sep 1;333(1):170-8
J:36360 Fernandez-Salguero PM, et al., Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol Appl Pharmacol. 1996 Sep;140(1):173-9
J:46346 Mimura J, et al., Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells. 1997 Oct;2(10):645-54
J:59890 Shimizu Y, et al., Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):779-82
J:64483 Lahvis GP, et al., Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10442-7
J:80189 Antenos M, et al., Interaction with Nedd8, a Ubiquitin-like Protein, Enhances the Transcriptional Activity of the Aryl Hydrocarbon Receptor. J Biol Chem. 2002 Nov 15;277(46):44028-34
J:84440 Bradfield CA, et al., Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse. Mol Pharmacol. 1991 Jan;39(1):13-9
J:115544 Puga A, et al., Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem Biol Interact. 2002 Sep 20;141(1-2):117-30
J:162974 Xu CX, et al., Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene. Toxicol Sci. 2010 May;115(1):98-108
J:206107 Wu D, et al., Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain. Mol Cell Biol. 2013 Nov;33(21):4346-56
J:236961 Ogiso H, et al., Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex. Biochemistry. 2004 Dec 14;43(49):15510-9
J:242131 Seok SH, et al., Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5431-5436
J:265123 Zhou Y, et al., A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa. Hum Mol Genet. 2018 Jul 15;27(14):2563-2572
J:300865 Kim JH, et al., Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Nat Commun. 2021 Jan 12;12(1):290