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Sequence Detail
ID/Version
P29477 Q5SXT3 O70515 Q6P6A0 O70516 Q8R410 (UniProt | EBI) Last sequence update: 1993-04-01
Last annotation update: 2019-09-18
Sequence
description
from provider
RecName: Full=Nitric oxide synthase, inducible; EC=1.14.13.39;AltName: Full=Inducible NO synthase; Short=Inducible NOS; Short=iNOS;AltName: Full=Macrophage NOS; Short=MAC-NOS;AltName: Full=NOS type II;AltName: Full=Peptidyl
Provider SWISS-PROT
Sequence
Polypeptide 1144 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Nos2 nitric oxide synthase 2, inducible 88 14 11 15
Sequence references in MGI J:528 Xie QW, et al., Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science. 1992 Apr 10;256(5054):225-8
J:1709 Lowenstein CJ, et al., Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6711-5
J:2324 Lyons CR, et al., Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 1992 Mar 25;267(9):6370-4
J:39499 Kone BC, et al., Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line. Am J Physiol. 1995 Nov;269(5 Pt 2):F718-29
J:56752 Teuscher C, et al., Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. J Immunol. 1999 Aug 15;163(4):2262-6
J:58509 Ghosh DK, et al., Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction. EMBO J. 1999 Nov 15;18(22):6260-70
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:162874 Kuang Z, et al., The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. J Cell Biol. 2010 Jul 12;190(1):129-41
J:168203 Kim SF, et al., Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005 Dec 23;310(5756):1966-70
J:180997 Niu S, et al., The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice. PLoS One. 2011;6(11):e26954

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory