Sequence Detail

ID/Version

P29452 (UniProt | EBI)

Last sequence update: 1993-04-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Caspase-1; Short=CASP-1; EC=3.4.22.36 {ECO:0000269|PubMed:18667412, ECO:0000269|PubMed:21147462, ECO:0000269|PubMed:35705808};AltName: Full=Interleukin-1 beta convertase; Short=IL-1BC;AltName: Full=Interleukin-1 beta-

Provider

SWISS-PROT

Sequence

Polypeptide 402 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Casp1	caspase 1	118	105	3	24

Sequence references in MGI

J:3172 Nett MA, et al., Molecular cloning of the murine IL-1 beta converting enzyme cDNA. J Immunol. 1992 Nov 15;149(10):3254-9
J:17638 Casano FJ, et al., The structure and complete nucleotide sequence of the murine gene encoding interleukin-1 beta converting enzyme (ICE). Genomics. 1994 Apr;20(3):474-81
J:17952 Molineaux SM, et al., Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1809-13
J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
J:188026 Erener S, et al., Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes. Mol Cell. 2012 Apr 27;46(2):200-11
J:243901 Wang Y, et al., Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection. Immunity. 2017 Mar 21;46(3):393-404
J:273511 Choi YJ, et al., SERPINB1-mediated checkpoint of inflammatory caspase activation. Nat Immunol. 2019 Mar;20(3):276-287
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296118 Wang K, et al., Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell. 2020 Mar 5;180(5):941-955.e20
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:306581 Broz P, et al., Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe. 2010 Dec 16;8(6):471-83
J:326897 Nozaki K, et al., Caspase-7 activates ASM to repair gasdermin and perforin pores. Nature. 2022 Jun;606(7916):960-967
J:326901 Lamkanfi M, et al., Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics. 2008 Dec;7(12):2350-63