Sequence Detail

ID/Version

P29352 Q7TMP9 (UniProt | EBI)

Last sequence update: 1992-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosine-protein phosphatase non-receptor type 22; EC=3.1.3.48 {ECO:0000269|PubMed:1373816, ECO:0000269|PubMed:27043286};AltName: Full=Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP;AltName: Full=PEST-domain phosphatase;

Provider

SWISS-PROT

Sequence

Polypeptide 802 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	94	97	3	23

Sequence references in MGI

J:32702 Matthews RJ, et al., Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol. 1992 May;12(5):2396-405
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:169817 Cloutier JF, et al., Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J. 1996 Sep 16;15(18):4909-18
J:169898 Liu J, et al., A biosynthetic pathway for anandamide. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13345-50
J:180575 Watanabe N, et al., Leupaxin binds to PEST domain tyrosine phosphatase PEP. Mol Cell Biochem. 2005 Jan;269(1-2):13-7
J:208241 Wang Y, et al., The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity. 2013 Jul 25;39(1):111-22
J:221551 Spalinger MR, et al., Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy. PLoS One. 2013;8(8):e72384
J:234957 Spalinger MR, et al., NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. J Clin Invest. 2016 May 2;126(5):1783-800
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89