Sequence Detail

ID/Version

P29121 Q62094 (UniProt | EBI)

Last sequence update: 1992-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Proprotein convertase subtilisin/kexin type 4; EC=3.4.21.-;AltName: Full=KEX2-like endoprotease 3;AltName: Full=Neuroendocrine convertase 3; Short=NEC 3;AltName: Full=Prohormone convertase 3;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 655 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pcsk4	proprotein convertase subtilisin/kexin type 4	29	99	2	7

Sequence references in MGI

J:17407 Mbikay M, et al., Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms. Genomics. 1994 Mar 15;20(2):231-7
J:27312 Nakayama K, et al., Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression. J Biol Chem. 1992 Mar 25;267(9):5897-900
J:41503 Mbikay M, et al., Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6842-6
J:107011 Gyamera-Acheampong C, et al., Sperm from Mice Genetically Deficient for the PCSK4 Proteinase Exhibit Accelerated Capacitation, Precocious Acrosome Reaction, Reduced Binding to Egg Zona Pellucida, and Impaired Fertilizing Ability. Biol Reprod. 2006 Apr;74(4):666-73
J:233570 Tardif S, et al., Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice. Mol Hum Reprod. 2012 Jun;18(6):298-307
J:233572 Iamsaard S, et al., Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization. J Cell Physiol. 2011 Nov;226(11):2817-26
J:233577 Gyamera-Acheampong C, et al., PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation. Fertil Steril. 2010 Mar 1;93(4):1112-23
J:233590 Tadros H, et al., The testicular germ-cell protease PC4 is also expressed in macrophage-like cells of the ovary. J Reprod Immunol. 2001 Feb;49(2):133-52