Sequence Detail

ID/Version

P28352 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=DNA repair nuclease/redox regulator APEX1; EC=3.1.11.2 {ECO:0000250|UniProtKB:P27695}; EC=3.1.21.- {ECO:0000250|UniProtKB:P27695};AltName: Full=APEX nuclease; Short=APEN;AltName: Full=Apurinic-apyrimidinic endonucleas

Provider

SWISS-PROT

Sequence

Polypeptide 317 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Apex1	apurinic/apyrimidinic endonuclease 1	79	103	3	18

Sequence references in MGI

J:11535 Seki S, et al., cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. J Biol Chem. 1991 Nov 5;266(31):20797-802
J:21514 Takiguchi Y, et al., Genomic structure of the mouse apurinic/apyrimidinic endonuclease gene. Mamm Genome. 1994 Nov;5(11):717-22
J:23896 Akiyama K, et al., Cloning, sequence analysis, and chromosomal assignment of the mouse Apex gene. Genomics. 1995 Mar 1;26(1):63-9
J:128500 Guikema JE, et al., APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med. 2007 Nov 26;204(12):3017-26
J:151678 Sabouri Z, et al., Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. Int Immunol. 2009 Aug;21(8):947-55
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89