Sequence Detail

ID/Version

P28033 (UniProt | EBI)

Last sequence update: 1992-08-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=CCAAT/enhancer-binding protein beta {ECO:0000312|MGI:MGI:88373}; Short=C/EBP beta;AltName: Full=AGP/EBP;AltName: Full=Interleukin-6-dependent-binding protein; Short=IL-6DBP;AltName: Full=Liver-enriched transcriptional activat

Provider

SWISS-PROT

Sequence

Polypeptide 296 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cebpb	CCAAT/enhancer binding protein beta	181	126	3	24

Sequence references in MGI

J:23758 Cao Z, et al., Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 1991 Sep;5(9):1538-52
J:26489 Chang CJ, et al., Autoregulated induction of the acute-phase response transcription factor gene, agp/ebp. DNA Cell Biol. 1995 Jun;14(6):529-37
J:27206 Chang CJ, et al., Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol Cell Biol. 1990 Dec;10(12):6642-53
J:43075 Sterneck E, et al., An essential role for C/EBPbeta in female reproduction. Genes Dev. 1997 Sep 1;11(17):2153-62
J:49673 Greenbaum LE, et al., CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. J Clin Invest. 1998 Sep 1;102(5):996-1007
J:74346 Tahirov TH, et al., Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. Cell. 2002 Jan 11;108(1):57-70
J:94195 Begay V, et al., Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. Mol Cell Biol. 2004 Nov;24(22):9744-51
J:98010 Bezy O, et al., Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. J Biol Chem. 2005 Mar 25;280(12):11432-8
J:99017 Meng Q, et al., IFN-gamma-stimulated transcriptional activation by IFN-gamma-activated transcriptional element-binding factor 1 occurs via an inducible interaction with CAAAT/enhancer-binding protein-beta. J Immunol. 2005 May 15;174(10):6203-11
J:131157 Berberich-Siebelt F, et al., SUMOylation interferes with CCAAT/enhancer-binding protein beta-mediated c-myc repression, but not IL-4 activation in T cells. J Immunol. 2006 Apr 15;176(8):4843-51
J:133506 Buck M, et al., Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Mol Cell. 1999 Dec;4(6):1087-92
J:148702 Ohoka N, et al., The orphan nuclear receptor ROR{alpha} restrains adipocyte differentiation through a reduction of C/EBP{beta} activity and perilipin gene expression. Mol Endocrinol. 2009 Jun;23(6):759-71
J:150006 Smink JJ, et al., Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. EMBO J. 2009 Jun 17;28(12):1769-81
J:152000 Kajimura S, et al., Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009 Aug 27;460(7259):1154-8
J:153025 Uematsu S, et al., The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. J Immunol. 2007 Oct 15;179(8):5378-86
J:158514 Kowenz-Leutz E, et al., Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. EMBO J. 2010 Mar 17;29(6):1105-15
J:159084 Podust LM, et al., Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. J Biol Chem. 2001 Jan 5;276(1):505-13
J:161702 Chung SS, et al., Control of adipogenesis by the SUMO-specific protease SENP2. Mol Cell Biol. 2010 May;30(9):2135-46
J:181181 Wang W, et al., Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med. 2012;18(2):235-43
J:219047 Liu Y, et al., Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein beta (C/EBPbeta) during adipogenesis. Mol Cell Biol. 2013 Nov;33(22):4606-17
J:219094 Cesena TI, et al., Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription. Mol Cell Endocrinol. 2008 Jul 16;289(1-2):94-101
J:219098 Wiper-Bergeron N, et al., Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2703-8
J:224721 Zhao Y, et al., p300-dependent acetylation of activating transcription factor 5 enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1 differentiation. Mol Cell Biol. 2014 Feb;34(3):315-24
J:237490 Brunmeir R, et al., Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PLoS Genet. 2016 Dec;12(12):e1006474
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89