Sequence Detail

ID/Version

P27782 (UniProt | EBI)

Last sequence update: 1992-08-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Lymphoid enhancer-binding factor 1 {ECO:0000312|MGI:MGI:96770}; Short=LEF-1 {ECO:0000303|PubMed:1827423};

Provider

SWISS-PROT

Sequence

Polypeptide 397 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lef1	lymphoid enhancer binding factor 1	191	235	3	22

Sequence references in MGI

J:12923 Travis A, et al., LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] [published erratum appears in Genes Dev 1991 Jun;5(6):following 1113]. Genes Dev. 1991 May;5(5):880-94
J:14749 Fujimoto S, et al., Nucleotide sequence of a cDNA encoding an alternative form of LEF-1. Nucleic Acids Res. 1993 Sep 11;21(18):4403
J:36231 Chen Y, et al., Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development. 1996 Oct;122(10):3035-44
J:55937 DasGupta R, et al., Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development. 1999 Oct;126(20):4557-68
J:73179 Sachdev S, et al., PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev. 2001 Dec 1;15(23):3088-103
J:117301 Melichar HJ, et al., Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Science. 2007 Jan 12;315(5809):230-3
J:127975 Merrill BJ, et al., Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev. 2001 Jul 1;15(13):1688-705
J:173032 Lukas J, et al., Dazap2 modulates transcription driven by the Wnt effector TCF-4. Nucleic Acids Res. 2009 May;37(9):3007-20
J:196163 Malhotra N, et al., A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 2013 Apr 18;38(4):681-93
J:237943 Jia S, et al., Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Dev Biol. 2016 Dec 01;420(1):110-119
J:341423 Feng XY, et al., Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Eur J Oral Sci. 2018 Feb;126(1):1-12