Sequence Detail

ID/Version

P27699 Q5XTP9 Q5XTP8 Q99JF1 P27698 Q5XTQ1 Q5XTQ2 Q5XTQ0 Q5XTQ3 (UniProt | EBI)

Last sequence update: 2009-09-22
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=cAMP-responsive element modulator;AltName: Full=Inducible cAMP early repressor; Short=ICER;

Provider

SWISS-PROT

Sequence

Polypeptide 357 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Crem	cAMP responsive element modulator	35	114	4	26

Sequence references in MGI

J:17941 Foulkes NS, et al., Developmental switch of CREM function during spermatogenesis: from antagonist to activator. Nature. 1992 Jan 2;355(6355):80-4
J:18605 Foulkes NS, et al., CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell. 1991 Feb 22;64(4):739-49
J:51709 Molina CA, et al., Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell. 1993 Dec 3;75(5):875-86
J:64956 Fimia GM, et al., CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature. 1999 Mar 11;398(6723):165-9
J:113459 Nagamori I, et al., Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation. J Biol Chem. 2006 Jun 2;281(22):15073-81
J:197826 Zmrzljak UP, et al., Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks. J Biol Chem. 2013 Apr 12;288(15):10318-27
J:263429 Fu G, et al., Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117. Biosci Biotechnol Biochem. 2016 Jun;80(6):1088-94
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89