Sequence Detail

ID/Version

P27671 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ras-specific guanine nucleotide-releasing factor 1; Short=Ras-GRF1;AltName: Full=CDC25Mm;AltName: Full=Guanine nucleotide-releasing protein; Short=GNRP;AltName: Full=Ras-specific nucleotide exchange factor CDC25;

Provider

SWISS-PROT

Sequence

Polypeptide 1262 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1	35	108	3	17

Sequence references in MGI

J:1145 Martegani E, et al., Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator. EMBO J. 1992 Jun;11(6):2151-7
J:3087 Cen H, et al., Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24. EMBO J. 1992 Nov;11(11):4007-15
J:39232 Wei W, et al., Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7100-4
J:72190 Gnesutta N, et al., Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1. J Biol Chem. 2001 Oct 19;276(42):39448-54
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89