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Sequence Detail
ID/Version
P27005 P31724 (UniProt | EBI) Last sequence update: 2007-01-23
Last annotation update: 2014-02-19
Sequence
description
from provider
RecName: Full=Protein S100-A8;AltName: Full=Calgranulin-A;AltName: Full=Chemotactic cytokine CP-10;AltName: Full=Leukocyte L1 complex light chain;AltName: Full=Migration inhibitory factor-related protein 8; Short=MRP-8; Short=p8;AltName: F
Provider SWISS-PROT
Sequence
Polypeptide 89 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene S100a8 S100 calcium binding protein A8 (calgranulin A) 30 1 5 3
Sequence references in MGI J:1255 Lagasse E, et al., Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood. 1992 Apr 15;79(8):1907-15
J:17391 Lackmann M, et al., Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10. J Immunol. 1993 Apr 1;150(7):2981-91
J:31265 Nacken W, et al., Molecular characterisation of the genomic locus of the mouse MRP8 gene. Biochim Biophys Acta. 1996 Jan 17;1315(1):1-5
J:56750 Passey RJ, et al., A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. J Immunol. 1999 Aug 15;163(4):2209-16
J:125179 Vogl T, et al., Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med. 2007 Sep;13(9):1042-9
J:140757 Lim SY, et al., S-nitrosylated S100A8: novel anti-inflammatory properties. J Immunol. 2008 Oct 15;181(8):5627-36
J:149024 Boyd JH, et al., S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res. 2008 May 23;102(10):1239-46

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory